Risk factors associated with persistent ocular inflammation in patients with Vogt-Koyanagi-Harada disease
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Yes
Purpose
To identify risk factors for persistent ocular inflammation in patients with Vogt-Koyanagi-Harada disease(VKH).
Methods
The clinical data of 52 patients diagnosed with VKH and treated with high dose steroid therapy, with whom we could followed up over one year were used for the statistical analysis. We defined the persistent VKH, which had any of inflammation with either more than "2+" cells (10-30 cells per field) in the anterior chamber, iris posterior synechia, or posterior ocular inflammation, which reguired additional treatments. We statistically investigated the association with the persistent VKH and their clinical data including age, gender, clinical findings, laboratory findings (blood, cerebrospinal fluid), and period from onset to treatment by using multivariate analysis.
Results
There were 18 (35%) male and 34 (65%) female with a mean age of 49.9±17.1 years. 12 of 52 patients (23%) had chronic ocular inflammation. The mean follow-up period was 34.8±23.4months. The estimated glomerular filtration rate (eGFR) in blood examination significantly associated with chronic VKH (P=0.0328). Age, gender, the number of cerebrospinal fluid cells, and period from onset to treatment did not show any significant association with persistent VKH.
Conclusion
The renal function could be a prognostic factor for persistent ocular inflammation in patients with VKH.
Conflict of interest
No
Author 1
Last name
YAMANA
Initials of first name(s)
S
City
Fukuoka
Country
Japan
Author 2
Last name
HASEGAWA
Initials of first name(s)
E
City
Fukuoka
Country
Japan
Author 3
Last name
TAKEDA
Initials of first name(s)
A
City
Fukuoka
Country
Japan
Author 4
Last name
YAWATA
Initials of first name(s)
N
City
Fukuoka
Country
Japan
Author 5
Last name
SONODA
Initials of first name(s)
K
City
Fukuoka
Country
Japan
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