Periocular vs. Intravitreal Steroids for Uveitic Macular Edema: A Real-World POINT Study
Accept poster if oral is not possible ?
No
Purpose
To study the effects of regional corticosteroid injections of periocular triamcinolone acetonide (PTA), intravitreal triamcinolone acetonide (ITA), and intravitreal dexamethasone implant (IDI) on uveitic macular edema (ME).
Methods
Retrospective cohort study of patients with non-infectious uveitis with ME comparing three treatment groups: PTA-40mg, ITA-4mg, and IDI-0.7mg. Analyses included change in central subfield thickness (CST), best-corrected visual acuity (VA), and intraocular pressure (IOP) at weeks 8 and 24, as well as incidence of additional injection over one year.
Results
Study included 140 eyes of 102 patients. At week-8, CST and VA improved within all groups (p<0.001), and IOP was elevated within all groups (p=0.003, 0.015, 0.046, for PTA, ITA, IDI, respectively). At week-24, CST remained improved within all groups (p<0.001); VA remained improved only with PTA and IDI (p<0.001, p=0.013 for PTA, IDI, respectively), but not with ITA; and IOP no longer remained elevated within any group. At week-8, comparison across groups showed CST had greater improvement with IDI (p=0.007), but there were no differences in VA and IOP. At week-24, there were no differences across groups in CST, VA, or IOP. Over one year, 51.4% of eyes were treated with additional injections. The IDI group was more likely to be treated with additional injections (p=0.038).
Conclusion
PTA, ITA, and IDI are effective in treating uveitic ME with sustained improvement in CST and VA and transient elevation of IOP. IDI showed greater improvement in CST at week-8 and was more likely to be treated with additional injections over one year.
Conflict of interest
No
1
Last name
HOSSAIN
Initials of first name(s)
HA
Department
Department of Ophthalmology, Emory University School of Medicine
City
Atlanta, Georgia
Country
United States
2
Last name
SONUGA
Initials of first name(s)
A
Department
Department of Ophthalmology, Emory University School of Medicine
City
Atlanta, Georgia
Country
United States
3
Last name
DODD
Initials of first name(s)
M
Department
Department of Ophthalmology, Emory University School of Medicine
City
Atlanta, Georgia
Country
United States
4
Last name
OU
Initials of first name(s)
X
Department
Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University
City
Atlanta, Georgia
Country
United States
5
Last name
CUI
Initials of first name(s)
X
Department
Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University
City
Atlanta, Georgia
Country
United States
6
Last name
O'KEEFE
Initials of first name(s)
GD
Department
Department of Ophthalmology, Emory University School of Medicine
City
Atlanta, Georgia
Country
United States
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