Janus kinase inhibitors, a new potential weapon in refractory scleritis and nonspecific orbital inflammation: a case series.
Accept poster if oral is not possible ?
Yes
Purpose
To highlight Janus kinase inhibitors (JAK-i) as a promising treatment for isolated orbital inflammatory disorders, presenting the first use of JAK-i in non-specific orbital inflammation (NSOI) and baricitinib in isolated scleritis, with the longest follow-up reported for JAK-i in isolated ocular inflammation.
Methods
Case series of two patients with isolated NSOI and refractory anterior scleritis. Comprehensive workups excluded infectious, rheumatological, and (para)neoplastic causes. JAK-i was initiated due to inflammation unresponsive to several DMARDs. Primary outcome: inflammation control; secondary outcome: adverse events.
Results
A 28-year-old female with isolated NSOI received tofacitinib as first-line, steroid-sparing treatment due to condition severity. A 46-year-old male with isolated anterior scleritis, previously treated with multiple DMARDs, received baricitinib. Both showed clinical improvement without relapses or serious side effects during a median follow-up of 21 months (range: 18–24 months).
Conclusion
This study demonstrates the first successful use of JAK-i in NSOI and baricitinib in isolated scleritis. JAK-i may be effective for refractory and severe isolated autoimmune NSOI and scleritis, with extended follow-up offering insights into long-term efficacy and safety. Collaboration between uveitis specialists and rheumatologists is essential for optimal outcomes.
Conflict of interest
No
1
Last name
VIDIC KRHLIKAR
Initials of first name(s)
N.
Department
Eye Hospital, University Medical Centre Ljubljana
City
Ljubljana
Country
Slovenia
2
Last name
TOMŠIČ
Initials of first name(s)
M.
Department
University Medical Centre Ljubljana, Department of Rheumatology
City
Ljubljana
Country
Slovenia
3
Last name
JAKI MEKJAVIĆ
Initials of first name(s)
P.
Department
Eye Hospital, University Medical Centre Ljubljana
City
Ljubljana
Country
Slovenia
4
Last name
KLOBUČAR
Initials of first name(s)
P.
Department
Eye Hospital, University Medical Centre Ljubljana
City
Ljubljana
Country
Slovenia
5
Last name
BREGAR
Initials of first name(s)
J.
Department
Eye Hospital, University Medical Centre Ljubljana
City
Ljubljana
Country
Slovenia
6
Last name
ŠURLAN POPOVIČ
Initials of first name(s)
K.
Department
Clinical institute of radiology, University Medical Centre Ljubljana
City
Ljubljana
Country
Slovenia
7
Last name
VIDOVIĆ VALENTINČIČ
Initials of first name(s)
N.
Department
Eye Hospital, University Medical Centre Ljubljana
City
Ljubljana
Country
Slovenia
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