Long-Term Efficacy and Safety of Topical Ganciclovir Solution in the Treatment of Cytomegalovirus Anterior Uveitis
Accept poster if oral is not possible ?
Yes
Purpose
To assess the long-term efficacy and safety of 2% topical Ganciclovir solution in treating cytomegalovirus (CMV) anterior uveitis.
Methods
This retrospective study involved patients diagnosed with recurrent CMV anterior uveitis via aqueous polymerase chain reaction at NTUH. Excluded were patients under 20 years or with less than 2 years of follow-up. Data collected included age, sex, affected eye, and CMV viral load. Non-treatment duration was defined as the time from the first episode to Ganciclovir initiation. Endothelial cell density (ECD) and retinal nerve fiber layer (RNFL) thickness were measured before and at least 2 years after treatment. Uveitis-related surgeries, including cataract surgery and trabeculectomy, were recorded. Relapse rates, ECD, and RNFL were compared pre- and post-treatment using paired t-tests, and risk factors for surgeries were analyzed via multivariate logistic regression.
Results
The study included 32 eyes of 32 patients (mean age: 54.9 ± 12.4 years; 21 men). The average non-treatment duration was 7.0 ± 6.5 years. Pre-treatment and post-treatment relapse rates were 8 ± 7.1 and 1 ± 0.7 episodes/person-year (p < 0.05), with 53.1% of patients having no relapses post-treatment. RNFL thickness significantly decreased (pre-treatment: 73.2 ± 15.2 μm, post-treatment: 70.3 ± 12.9 μm, p = 0.027), while ECD remained stable (pre-treatment: 1540.5 ± 625/mm², post-treatment: 1504.7 ± 801/mm², p = 0.672). Surgical interventions included cataract surgery (50%) and trabeculectomy (34.4%), with no patient characteristics linked to surgical risk.
Conclusion
Topical 2% Ganciclovir effectively prevents relapse and maintains ECD in patients with CMV anterior uveitis.
Conflict of interest
No
1
Last name
YEH
Initials of first name(s)
PT
Department
Department of Ophthalmology, National Taiwan University Hospital
City
Taipei
Country
Taiwan
2
Last name
Lin
Initials of first name(s)
CP
Department
Department of Ophthalmology, National Taiwan University Hospital
City
Taipei
Country
Taiwan
3
Last name
Wang
Initials of first name(s)
YH
Department
Department of Ophthalmology, National Taiwan University Hospital
City
Taipei
Country
Taiwan
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