Efficacy and Safety of Biosimilar Adalimumab (biADA, Hyrimoz®) in Behcet’s Uveitis
Accept poster if oral is not possible ?
Yes
Purpose
To evaluate the efficacy and safety of biosimilar adalimumab (biADA, Hyrimoz®) in patients with Behçet’s uveitis in Thailand, an endemic area for tuberculosis (TB).
Methods
We conducted a retrospective study on Behçet’s uveitis patients who failed conventional treatments and were anti-TNF naïve. The primary endpoint was improvement in logMAR best-corrected visual acuity (BCVA), with secondary endpoints including changes in central subfield thickness (CST), prednisolone dosage, ocular inflammation, and adverse reactions at six months following biosimilar adalimumab (biADA, Hyrimoz®) treatment.
Results
A total of 26 eyes from 14 patients were included, with a mean follow-up duration of 190 days. After 6 months of treatment with biosimilar adalimumab (biADA), significant improvements were observed in logMAR BCVA (from 0.99 to 0.78, P = 0.032), CST (from 301.09 µm to 258.41 µm, P = 0.009), and prednisolone dosage (from 22.5 mg/day to 3.7 mg/day, P < 0.0001). Additionally, oral prednisolone dosage was significantly reduced within one month of biADA initiation, with half of the patients able to discontinue oral prednisolone entirely within 50 days. However, one patient developed active pulmonary tuberculosis after 4 months of biADA treatment, and another patient developed vitiligo on the skin.
Conclusion
Biosimilar adalimumab (biADA, Hyrimoz®) effectively improved visual outcomes, reduced ocular inflammation, and lowered corticosteroid use in Behçet’s uveitis. Careful monitoring for adverse events, like tuberculosis reactivation, is crucial in endemic areas. It offers an affordable alternative for managing Behçet’s uveitis in resource-limited settings.
Conflict of interest
No
1
Last name
PIYAPHINYOPHAP
Initials of first name(s)
Chak
Department
Department of Ophthalmology, Faculty of Medicine, Khon Kaen University
City
Khonkaen
Country
Thailand
2
Last name
LAOVIROJJANAKUL
Initials of first name(s)
Wipa
Department
Department of Ophthalmology, Faculty of Medicine, Khon Kaen University
City
Khonkaen
Country
Thailand
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