Long-term outcomes and risk factors for prognosis in elective and non-elective vitrectomies for uveitis patients
Purpose
To evaluate the long-term outcomes of pars plana vitrectomy(PPV) in uveitis patients and assess the effect of the surgical indication (elective or non-elective PPV) on these outcomes.
Methods
This is a retrospective review of the records of all patients who attended a uveitis clinic at Moorfields Eye Hospital, UK between 2011 to 2019. The patients included, had chronic uveitis treated with topical or systemic therapy and PPV and had a minimum 5 year-follow-up post PPV.
Results
Overall, 77 patients were included and classified in non-elective (nE-PPV) group (35 patients) and elective PPV (E-PPV) group (33 patients). The significant differences between the 2 groups were the PPV indications (nE-PPV: retinal detachment (84.6%); E-PPV: epiretinal membrane (45.2%)), the time from the last flare-up to PPV (nE-PPV: 3.3 ± 4.6 months; E-PPV: 9.0 ± 8.2 months) and the BCVA gain more than 2 lines at 1 year post PPV (nE-PPV: 33.3%; E-PPV: 66.7%). The postoperative relapses in the 2 groups were associated with the age, the presence of panuveitis and long duration of disease. The factors contributing to post-PPV BCVA indicated that after adjusting for time and surgical type, E-PPV compared to nE-PPV was estimated to improve logMAR BCVA by -0.30(P=0.037); poor baseline BCVA was associated with BCVA decrease by 0.63(P<0.001); and improvement of BCVA at 1 year follow-up compared to baseline was associated with -0.17 estimate better of BCVA(P=0.008).
Conclusion
Our study showed that whether urgent or elective PPV in treating uveitis could be beneficial for the post-PPV visual outcomes. Importantly, the first postoperative year BCVA could play a detrimental factor for the long-term visual outcomes.
Conflict of interest
No
Authors 1
Last name
TASIOPOULOU
Initials of first name(s)
A
Department
Eye Center of Athens, Moorfields Eye Hospital
City
Athens
Country
Greece
Authors 2
Last name
Chen
Initials of first name(s)
YH
Department
Ophthalmology, Chang Gung Memorial Hospital, Linkou medical center, Moorfields Eye Hospital
City
Taoyuan
Country
Taiwan
Authors 3
Last name
Lavnish
Initials of first name(s)
J
Department
UCL Institute of Ophthalmology, Moorfields Eye Hospital
City
London
Country
United Kingdom
Authors 4
Last name
Lightman
Initials of first name(s)
S
Department
UCL Institute of Ophthalmology, Moorfields Eye Hospital
City
London
Country
United Kingdom
Authors 5
Last name
Tomkins-Netzer
Initials of first name(s)
O
Department
UCL Institute of Ophthalmology, Moorfields Eye Hospital, Lady Davis Carmel Medical Center
City
Haifa
Country
Israel
This website uses cookies to ensure you get the best experience on our website.
Learn more